I am running Vista SP1 64-bit Business with RegVac V5.01.22.  I can backup my registry and it places the backup in C:\Windows\System32\RegVac properly.  However, when I select the "Clean up Backup" option, RegVac responds with "No RegVac Registry Backups Found".

The backups are definitely located in C:\Windows\System32\RegVac.  

I have tried RegVac "Run as Administrator", but the problem still exists.  I am running via the Expert Zone in RegVac

   I tried RegVac in Vista and did not have a problem.
   When you click on the Clean up Backups button, RegVac looks to see if the C:\Windows\System32\RegVac directory exists.  You get that error because it is not finding that directory.  Maybe you have the security settings for that folder so that it does not appear.  I don't know.  Or there could be some other reason that it cannot see the directory on your computer.

It seems inconsistent with being a Security setting issue.  RegVac creates the folder and also successfully writes backups into the folder.  Thus it should be able to find the folder for cleaning.  

   I agree.  It should be able to find the folder.  But if you get that error, it is not.  On the computers that I have tested it on, it finds the folder.  It is only on your computer that it is not.  I don't know why that is.
   I have looked at the code of WinRescue and the only thing that WinRescue does is it uses the Windows "Find Directory" procedure to find the C:\Windows\System32\RegVac folder and it is returning false.

Well, it works fine on my XP-SP3 machine and on my Vista SP1 32bit machine; however, not on Vista SP1 64bit.  

I am running Vista SP1 64-bit Vista with a registered RegVac V5.01.24.

There is a bug in the Backup component of RegVac.

1.  When the Backup is made, it is stored in C:\Windows\System32\RegVac

2.  When a CleanUp is attempted, RegVac looks for the RegVac folder in C:\Windows\SysWOW64 folder.  This location error results in no registry backups being found...thus no cleanup.

How did I confirm this?

I copied/pasted the RegVac folder from C:\Windows\System32 into C:\Windows\SysWOW64.  Then the Cleaner component found the backed up registry and cleaned it.

This problem has been quickly resolved in V5.0.1.25.

Thanks much

   When you mentioned the SysWOW64 folder, I realized what the problem was (thanks for figuring that part out).  x64 keeps its drivers in two locations: one for 32 bit and one for 64bit.  That part of RegVac was just looking in one of those locations.  Other parts of RegVac look in both locations, I just had missed that for the Clean button.  Now it is fixed.