If you are using an optical mouse the same symptoms can also be caused by having the mouse on a surface with patterns on it. IE: a "pretty" mouse pad. If the mouse "lights up" it is generally an optical mouse.
Try removing the mouse pad, and just use the desk. Or put a single colored paper under the mouse.
Basically the colored patterns on the mouse pad can confuse the mouse.
If it's not an optical mouse and since you already tried another mouse, I would have to say it is not just dirty mouse wheels.
That being the case, then I second dlwolff0's comments.
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