Running a registry cleaning on Vista SP1 64-bit with the new Raxco PerfectDisk 10 defragger cripples PerfectDisk 10.  This did not occur with PerfectDisk 2008.

Among the invalidly cleaned key are:

Key Name:          HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Control\Session Manager\PDUnmovableFiles
Class Name:        <NO CLASS>
Last Write Time:   1/29/2009 - 2:09 AM
Value 0
  Name:            safeboot.fs
  Type:            REG_SZ
  Data:            C:\safeboot.fs

Value 1
  Name:            safeboot.csc
  Type:            REG_SZ
  Data:            C:\safeboot.csc

Value 2
  Name:            safeboot.rsv
  Type:            REG_SZ
  Data:            C:\safeboot.rsv

Value 3
  Name:            $ISRBIN
  Type:            REG_SZ
  Data:            C:\$ISR\0\$ISRBIN

Value 4
  Name:            BootStat.dat
  Type:            REG_SZ
  Data:            C:\Windows\bootstat.dat

Value 5
  Name:            System Volume Information
  Type:            REG_SZ
  Data:            C:\System Volume Information

Several other keys in ControlSet001 and ControlSet002 are invalidly removed.

[HKEY_LOCAL_MACHINE\SYSTEM\ControlSet001\Control\Session Manager\PDUnmovableFiles]
"safeboot.fs"=""
"safeboot.csc"=""
"safeboot.rsv"=""
"$ISRBIN"=""

[HKEY_LOCAL_MACHINE\SYSTEM\ControlSet002\Control\Session Manager\PDUnmovableFiles]
"safeboot.fs"=""
"safeboot.csc"=""
"safeboot.rsv"=""
"$ISRBIN"=""

   Just select them in the Undo section and click on the Ignore button.
   My guess as to why they are removed is because they do not exist in the location that it says they exist.  My guess is also that you are running RegVac in the Expert Zone which suggests that it may not be 100% correct.
   If you confirm that the above entries are causing that problem, I will enter them permanently into the Ignore list of RegVac.

I typically run in Expert mode.  However, even in Novice Mode, it cripples PD 10.  The Undo option does not repair the registry because something is blocking it the Undo of the PD 10 registry keys.  An error message is issued by RegVac that it cannot undo all the keys.  Even in SAFE MODE, it cannot restore.

PerfectDisk 10 has to be uninstalled and re-installed to correct the failures.  I haven't been able to figure out what other keys are being improperly removed.  

   It must not be one of those keys that is the problem.  It usually is only one entry that causes a problem like that.